In October 2003, a group of freshman students who resided in Ball Residence Hall at Indiana University - Purdue University Indianapolis became interested in integrating student life with this traditionally commuter based campus. After a long search for the right fraternity, Tau Kappa Epsilon became the right choice. The principles of Tau Kappa Epsilon most aligned with the goals of these young men.

Once Tau Kappa Epsilon was selected, it was time to begin the journey into Chartering. Colony #788 was officially recognized as an embodiment of the International Fraternity on March 17, 2004. With the support of the International Headquarters this group began their education and recruitment of new members.

In March of 2005, Franklin College initiated the first group of men from Indiana University Purdue University at Indianapolis, into the bond of Tau Kappa Epsilon. The chapter officially received its chapter designation of Upsilon Iota on August 20, 2005 at a wonderful Chartering Banquet.

Since their founding at IUPUI, they have been able to participate in many on campus events including MLK Day of Service, Freshman Move-in, Jag-a-thon, Relay for Life and Weeks of Welcome events. They have also been judges for a local science fair and have volunteered in numerous places in the Indianapolis community. This group of men is a diverse group united by the common brotherhood of Tau Kappa Epsilon who hope to make IUPUI a better place to live and attend school for all students.